The role of MBL2 gene polymorphism in sepsis incidence.

ABSTRACT:

Aim

This case-control study was aimed to explore the role of mannose-binding lectin 2 (MBL2) gene rs1800450 polymorphism (codon 54 A/B, G230A) in the development of sepsis in Han Chinese.

Methods

MBL2 rs1800450 polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). MBL serum level was detected by enzyme-linked immunosorbent assay (ELISA). Associations between rs1800450 and sepsis susceptibility was detected by Chi-square test and represented by odds ratios (ORs) and 95% confidence intervals (CIs). Correlation of rs1800450 genotypes and MBL serum level was assessed using t test.

Result

Variant A allele frequency was significantly observed in cases than that in controls, indicating a significant association with the

SUBMITTER: Liu L 

PROVIDER: S-EPMC4713640 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature