Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Y
PROVIDER: S-EPMC4714217 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Yuan Yiyuan Y Hakimi Parvin P Kao Clara C Kao Allison A Liu Ruifu R Janocha Allison A Boyd-Tressler Andrea A Hang Xi X Alhoraibi Hanna H Slater Erin E Xia Kevin K Cao Pengxiu P Shue Quinn Q Ching Tsui-Ting TT Hsu Ao-Lin AL Erzurum Serpil C SC Dubyak George R GR Berger Nathan A NA Hanson Richard W RW Feng Zhaoyang Z
The Journal of biological chemistry 20151202 3
Aging involves progressive loss of cellular function and integrity, presumably caused by accumulated stochastic damage to cells. Alterations in energy metabolism contribute to aging, but how energy metabolism changes with age, how these changes affect aging, and whether they can be modified to modulate aging remain unclear. In locomotory muscle of post-fertile Caenorhabditis elegans, we identified a progressive decrease in cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), a longevity-associ ...[more]