Ontology highlight
ABSTRACT:
SUBMITTER: Ng KW
PROVIDER: S-EPMC4714483 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Ng Kevin W KW Anderson Christine C Marshall Erin A EA Minatel Brenda C BC Enfield Katey S S KS Saprunoff Heather L HL Lam Wan L WL Martinez Victor D VD
Molecular cancer 20160115
PIWI-interacting RNAs (piRNAs) are emerging players in cancer genomics. Originally described in the germline, there are over 20,000 piRNA genes in the human genome. In contrast to microRNAs, piRNAs interact with PIWI proteins, another member of the Argonaute family, and function primarily in the nucleus. There, they are involved in the epigenetic silencing of transposable elements in addition to the transcriptional regulation of genes. It has recently been demonstrated that piRNAs are also expre ...[more]