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Spotlight on ixazomib: potential in the treatment of multiple myeloma.


ABSTRACT: Despite the significant therapeutic advances achieved with proteasome inhibitors (PIs) such as bortezomib and carfilzomib in prolonging the survival of patients with multiple myeloma, the development of drug resistance, peripheral neuropathy, and pharmacokinetic limitations continue to pose major challenges when using these compounds. Ixazomib is a second-generation PI with improved activity over other PIs. Unlike bortezomib and carfilzomib, which are administered by injection, ixazomib is the first oral PI approved by US Food and Drug Administration. This review discusses the biochemical properties, mechanisms of action, preclinical efficacy, and clinical trial results leading to the US Food and Drug Administration approval of ixazomib.

SUBMITTER: Muz B 

PROVIDER: S-EPMC4714737 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Spotlight on ixazomib: potential in the treatment of multiple myeloma.

Muz Barbara B   Ghazarian Rachel Nicole RN   Ou Monica M   Luderer Micah John MJ   Kusdono Hubert Daniel HD   Azab Abdel Kareem AK  

Drug design, development and therapy 20160111


Despite the significant therapeutic advances achieved with proteasome inhibitors (PIs) such as bortezomib and carfilzomib in prolonging the survival of patients with multiple myeloma, the development of drug resistance, peripheral neuropathy, and pharmacokinetic limitations continue to pose major challenges when using these compounds. Ixazomib is a second-generation PI with improved activity over other PIs. Unlike bortezomib and carfilzomib, which are administered by injection, ixazomib is the f  ...[more]

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