MiR-1303 Regulates Mycobacteria Induced Autophagy by Targeting Atg2B.
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ABSTRACT:
SUBMITTER: Au KY
PROVIDER: S-EPMC4714759 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
MiR-1303 Regulates Mycobacteria Induced Autophagy by Targeting Atg2B.
Au Kin Yi KY Pong John C H JC Ling Wai Lim WL Li James C B JC
PloS one 20160115 1
MicroRNAs are emerging post-transcriptional regulators of gene expressions in both innate immunity and adaptive immunity. In mycobacteria infection, autophagy plays an important role in innate defense mechanism and is tightly regulated by the autophagy-related proteins. Here, we show that Atg2B is involved in the regulation of mycobacteria-induced autophagy. MiR-1303, which function is not defined yet, is found to negatively regulate mycobacteria-induced Atg2B protein production, ultimately down ...[more]
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