Ontology highlight
ABSTRACT:
SUBMITTER: Willuhn I
PROVIDER: S-EPMC4714770 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Willuhn Ingo I Burgeno Lauren M LM Groblewski Peter A PA Phillips Paul E M PE
Nature neuroscience 20140406 5
Drug addiction is a neuropsychiatric disorder marked by escalating drug use. Dopamine neurotransmission in the ventromedial striatum (VMS) mediates acute reinforcing effects of abused drugs, but with protracted use the dorsolateral striatum is thought to assume control over drug seeking. We measured striatal dopamine release during a cocaine self-administration regimen that produced escalation of drug taking in rats. Surprisingly, we found that phasic dopamine decreased in both regions as the ra ...[more]