Ontology highlight
ABSTRACT:
SUBMITTER: Oda S
PROVIDER: S-EPMC4714835 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Oda Seiichiro S Nozawa Takashi T Nozawa-Minowa Atsuko A Tanaka Misako M Aikawa Chihiro C Harada Hiroyuki H Nakagawa Ichiro I
PloS one 20160115 1
Autophagy acts as a host-defense system against pathogenic microorganisms such as Group A Streptococcus (GAS). Autophagy is a membrane-mediated degradation system that is regulated by intracellular membrane trafficking regulators, including small GTPase Rab proteins. Here, we identified Rab30 as a novel regulator of GAS-containing autophagosome-like vacuoles (GcAVs). We found that Rab30, a Golgi-resident Rab, was recruited to GcAVs in response to autophagy induction by GAS infection in epithelia ...[more]