Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5.
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ABSTRACT:
SUBMITTER: Vijay-Kumar M
PROVIDER: S-EPMC4714868 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5.
Vijay-Kumar Matam M Aitken Jesse D JD Carvalho Frederic A FA Cullender Tyler C TC Mwangi Simon S Srinivasan Shanthi S Sitaraman Shanthi V SV Knight Rob R Ley Ruth E RE Gewirtz Andrew T AT
Science (New York, N.Y.) 20100304 5975
Metabolic syndrome is a group of obesity-related metabolic abnormalities that increase an individual's risk of developing type 2 diabetes and cardiovascular disease. Here, we show that mice genetically deficient in Toll-like receptor 5 (TLR5), a component of the innate immune system that is expressed in the gut mucosa and that helps defend against infection, exhibit hyperphagia and develop hallmark features of metabolic syndrome, including hyperlipidemia, hypertension, insulin resistance, and in ...[more]
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