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An Epitope-Specific Respiratory Syncytial Virus Vaccine Based on an Antibody Scaffold.


ABSTRACT: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in children. We have generated an epitope-specific RSV vaccine by grafting a neutralizing epitope (F-epitope) in its native conformation into an immunoglobulin scaffold. The resulting antibody fusion exhibited strong binding affinity to Motavizumab, an RSV neutralizing antibody, and effectively induced potent neutralizing antibodies in mice. This work illustrates the potential of the immunoglobulin molecule as a scaffold to present conformationally constrained B-cell epitopes.

SUBMITTER: Luo X 

PROVIDER: S-EPMC4715490 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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An Epitope-Specific Respiratory Syncytial Virus Vaccine Based on an Antibody Scaffold.

Luo Xiaozhou X   Liu Tao T   Wang Ying Y   Jia Haiqun H   Zhang Yuhan Y   Caballero Dawna D   Du Juanjuan J   Wang Rongsheng E RE   Wang Danling D   Schultz Peter G PG   Wang Feng F  

Angewandte Chemie (International ed. in English) 20151005 48


Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in children. We have generated an epitope-specific RSV vaccine by grafting a neutralizing epitope (F-epitope) in its native conformation into an immunoglobulin scaffold. The resulting antibody fusion exhibited strong binding affinity to Motavizumab, an RSV neutralizing antibody, and effectively induced potent neutralizing antibodies in mice. This work illustrates the potential of the immunoglobulin molecul  ...[more]

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2024-05-29 | GSE232687 | GEO