Ontology highlight
ABSTRACT:
SUBMITTER: Ekanger LA
PROVIDER: S-EPMC4715661 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Ekanger Levi A LA Polin Lisa A LA Shen Yimin Y Haacke E Mark EM Martin Philip D PD Allen Matthew J MJ
Angewandte Chemie (International ed. in English) 20151002 48
The Eu(II) ion rivals Gd(III) in its ability to enhance contrast in magnetic resonance imaging. However, all reported Eu(II)-based complexes have been studied in vitro largely because the tendency of Eu(II) to oxidize to Eu(III) has been viewed as a major obstacle to in vivo imaging. Herein, we present solid- and solution-phase characterization of a Eu(II)-containing cryptate and the first in vivo use of Eu(II) to provide contrast enhancement. The results indicate that between one and two water ...[more]