Dataset Information

Knee Osteoarthritis Worsening Across the Disease Spectrum and Future Knee Pain, Symptoms, and Functioning: A Multisite Prospective Cohort Study.

ABSTRACT: OBJECTIVE:Prognostic estimates for knee osteoarthritis worsening over the full disease spectrum have not been reported. Osteoarthritis Initiative data were used to determine the association between knee radiographic osteoarthritis worsening and future knee pain and function. METHODS:Yearly data over a 5-year period were analyzed. Outcome measures were the Western Ontario and McMaster Universities Osteoarthritis Index and the Knee Injury and Osteoarthritis Outcome Score pain and symptoms scales. Knees were grouped based on whether yearly Kellgren/Lawrence (K/L) grades worsened. Associations of yearly K/L worsening with knee pain, symptoms, or function scores at the end of the year and with lagged outcomes observed at least 1 year after worsening were assessed using linear models with generalized estimating equations. RESULTS:A total of 25,932 knee-years of observations were examined in the primary analysis. For knees with yearly K/L worsening, all outcome scores were significantly worse (P values from 0.02 to?<0.001) at the end of the index year, as compared to unchanged knees. All outcomes for knees with worsened versus unchanged K/L scores exceeded the minimal clinically important difference (MCID). For lagged effects, outcomes at 1 year following the index K/L year exceeded the MCID and were statistically significant (P ? 0.001) for knees with baseline K/L grades of 2 or 3. CONCLUSION:K/L worsening over a 1-year period is prognostically important over the short term for all baseline K/L grades, and for knees with baseline K/L grades of 2 or 3 worsening continues over the following year.

SUBMITTER: Riddle DL

PROVIDER: S-EPMC4715755 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Knee Osteoarthritis Worsening Across the Disease Spectrum and Future Knee Pain, Symptoms, and Functioning: A Multisite Prospective Cohort Study.

Riddle Daniel L DL Makowski Mateusz M Kong Xiangrong X

Arthritis care & research 20151201 12

<h4>Objective</h4>Prognostic estimates for knee osteoarthritis worsening over the full disease spectrum have not been reported. Osteoarthritis Initiative data were used to determine the association between knee radiographic osteoarthritis worsening and future knee pain and function.<h4>Methods</h4>Yearly data over a 5-year period were analyzed. Outcome measures were the Western Ontario and McMaster Universities Osteoarthritis Index and the Knee Injury and Osteoarthritis Outcome Score pain and sy ...[more]

PMID: 26212203

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Project description:BackgroundThe prevalence of knee osteoarthritis is traditionally based on radiographic findings, but magnetic resonance imaging is now being used to provide better visualization of bone, cartilage, and soft tissues as well as the patellar compartment. The goal of this study was to estimate the prevalences of knee features defined on magnetic resonance imaging in a population and to relate these abnormalities to knee osteoarthritis severity scores based on radiographic findings, physical functioning, and reported knee pain in middle-aged women.MethodsMagnetic resonance images of the knee were evaluated for the location and severity of cartilage defects, bone marrow lesions, osteophytes, subchondral cysts, meniscal and/or ligamentous tears, effusion, and synovitis among 363 middle-aged women (724 knees) from the Michigan Study of Women's Health Across the Nation. These findings were related to Kellgren-Lawrence osteoarthritis severity scores from radiographs, self-reported knee pain, self-reported knee injury, perception of physical functioning, and physical performance measures to assess mobility. Radiographs, physical performance assessment, and interviews were undertaken at the 1996 study baseline and again (with the addition of magnetic resonance imaging assessment) at the follow-up visit during 2007 to 2008.ResultsThe prevalence of moderate-to-severe knee osteoarthritis changed from 3.7% at the baseline assessment to 26.7% at the follow-up visit eleven years later. Full-thickness cartilage defects of the medial, lateral, and patellofemoral compartments were present in 14.5% (105 knees), 4.6% (thirty-three knees), and 26.2% (190 knees), respectively. Synovitis was identified in 24.7% (179) of the knees, and joint effusions were observed in 70% (507 knees); 21.7% (157) of the knees had complex or macerated meniscal tears. Large osteophytes, marked synovitis, macerated meniscal tears, and full-thickness tibial cartilage defects were associated with increased odds of knee pain and with 30% to 40% slower walking and stair-climbing times.ConclusionsMiddle-aged women have a high prevalence of moderate-to-severe knee osteoarthritis corroborated by strong associations with cartilage defects, complex and macerated meniscal tears, osteophytes and synovitis, knee pain, and lower mobility levels.

Dataset Information

Knee Osteoarthritis Worsening Across the Disease Spectrum and Future Knee Pain, Symptoms, and Functioning: A Multisite Prospective Cohort Study.

Publications

Knee Osteoarthritis Worsening Across the Disease Spectrum and Future Knee Pain, Symptoms, and Functioning: A Multisite Prospective Cohort Study.

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