SerpinB1 Promotes Pancreatic ? Cell Proliferation.
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ABSTRACT:
SUBMITTER: El Ouaamari A
PROVIDER: S-EPMC4715773 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
SerpinB1 Promotes Pancreatic β Cell Proliferation.
El Ouaamari Abdelfattah A Dirice Ercument E Gedeon Nicholas N Hu Jiang J Zhou Jian-Ying JY Shirakawa Jun J Hou Lifei L Goodman Jessica J Karampelias Christos C Qiang Guifeng G Boucher Jeremie J Martinez Rachael R Gritsenko Marina A MA De Jesus Dario F DF Kahraman Sevim S Bhatt Shweta S Smith Richard D RD Beer Hans-Dietmar HD Jungtrakoon Prapaporn P Gong Yanping Y Goldfine Allison B AB Liew Chong Wee CW Doria Alessandro A Andersson Olov O Qian Wei-Jun WJ Remold-O'Donnell Eileen E Kulkarni Rohit N RN
Cell metabolism 20151215 1
Although compensatory islet hyperplasia in response to insulin resistance is a recognized feature in diabetes, the factor(s) that promote β cell proliferation have been elusive. We previously reported that the liver is a source for such factors in the liver insulin receptor knockout (LIRKO) mouse, an insulin resistance model that manifests islet hyperplasia. Using proteomics we show that serpinB1, a protease inhibitor, which is abundant in the hepatocyte secretome and sera derived from LIRKO mic ...[more]
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