Ontology highlight
ABSTRACT:
SUBMITTER: Song M
PROVIDER: S-EPMC4715983 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Song Mia M He Qianjing Q Berk Benjamin-Andreas BA Hartwig John H JH Stossel Thomas P TP Nakamura Fumihiko F
Biochemical and biophysical research communications 20151217 3
Filamin A (FLNA) is an actin filament crosslinking protein with multiple intracellular binding partners. Mechanical force exposes cryptic FLNA binding sites for some of these ligands. To identify new force-dependent binding interactions, we used a fusion construct composed of two FLNA domains, one of which was previously identified as containing a force-dependent binding site as a bait in a yeast two-hybrid system and identified the Rho dissociation inhibitor 2 (RhoGDI2) as a potential interacti ...[more]