Ontology highlight
ABSTRACT:
SUBMITTER: Biel TG
PROVIDER: S-EPMC4716309 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Biel T G TG Lee S S Flores-Toro J A JA Dean J W JW Go K L KL Lee M-H MH Law B K BK Law M E ME Dunn W A WA Zendejas I I Behrns K E KE Kim J-S JS
Cell death and differentiation 20150717 2
Ischemia/reperfusion (I/R) injury is a major cause of morbidity and mortality after liver surgery. The role of Sirtuin 1 (SIRT1) in hepatic I/R injury remains elusive. Using human and mouse livers, we investigated the effects of I/R on hepatocellular SIRT1. SIRT1 expression was significantly decreased after I/R. Genetic overexpression or pharmacological activation of SIRT1 markedly suppressed defective autophagy, onset of the mitochondrial permeability transition, and hepatocyte death after I/R, ...[more]