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Agent-Based Modeling in Systems Pharmacology.

ABSTRACT: Modeling and simulation (M&S) techniques provide a platform for knowledge integration and hypothesis testing to gain insights into biological systems that would not be possible a priori. Agent-based modeling (ABM) is an M&S technique that focuses on describing individual components rather than homogenous populations. This tutorial introduces ABM to systems pharmacologists, using relevant case studies to highlight how ABM-specific strengths have yielded success in the area of preclinical mechanistic modeling.

SUBMITTER: Cosgrove J

PROVIDER: S-EPMC4716580 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Agent-Based Modeling in Systems Pharmacology.

Cosgrove J J Butler J J Alden K K Read M M Kumar V V Cucurull-Sanchez L L Timmis J J Coles M M

CPT: pharmacometrics & systems pharmacology 20151113 11

Modeling and simulation (M&S) techniques provide a platform for knowledge integration and hypothesis testing to gain insights into biological systems that would not be possible a priori. Agent-based modeling (ABM) is an M&S technique that focuses on describing individual components rather than homogenous populations. This tutorial introduces ABM to systems pharmacologists, using relevant case studies to highlight how ABM-specific strengths have yielded success in the area of preclinical mechanis ...[more]

PMID: 26783498

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