Ontology highlight
ABSTRACT:
SUBMITTER: Ren J
PROVIDER: S-EPMC4716616 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Ren Jing J Nie Yunzhong Y Lv Mingming M Shen Sunan S Tang Ruijing R Xu Yujun Y Hou Yayi Y Zhao Shuli S Wang Tingting T
Cellular & molecular immunology 20141103 6
Estrogen is involved in promoting lung cancer cell division and metastasis. MICA and MICB function as ligands for NKG2D, an important immunoreceptor expressed on natural killer (NK) cells. However, whether estrogen regulates MICA/B expression and affects tumor immune escape remains unknown. In this study, we measured the mRNA levels of MICA, MICB and ADAM17in non-small cell lung cancer (NSCLC) cell lines treated with estrogen. Surface expression of MICA/B on LTEP-a2 and A549 was detected using f ...[more]