Dataset Information

Prognostic value of preoperative intratumoral FDG uptake heterogeneity in early stage uterine cervical cancer.

ABSTRACT:

Objective

We investigated the prognostic value of intratumoral [¹?F]fluorodeoxyglucose (FDG) uptake heterogeneity (IFH) derived from positron emission tomography/computed tomography (PET/CT) in patients with cervical cancer.

Methods

Patients with uterine cervical cancer of the International Federation of Obstetrics and Gynecology (FIGO) stage IB to IIA were imaged with [¹?F]FDG PET/CT before radical surgery. PET/CT parameters such as maximum and average standardized uptake values (SUV(max) and SUV(avg)), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and IFH were assessed. Regression analyses were used to identify clinicopathological and imaging variables associated with progression-free survival (PFS).

Results

We retrospectively reviewed clinical data of 85 eligible patients. Median PFS was 32 months (range, 6 to 83 months), with recurrence observed in 14 patients (16.5%). IFH at an SUV of 2.0 was correlated with primary tumor size (p<0.001), SUV(tumor) (p<0.001), MTV(tumor) (p<0.001), TLG(tumor) (p<0.001), depth of cervical invasion (p<0.001), and negatively correlated with age (p=0.036). Tumor recurrence was significantly associated with TLG(tumor) (p<0.001), MTV(tumor) (p=0.001), SUV(LN) (p=0.004), IFH (p=0.005), SUV(tumor) (p=0.015), and FIGO stage (p=0.015). Multivariate analysis identified that IFH (p=0.028; hazard ratio, 756.997; 95% CI, 2.047 to 279,923.191) was the only independent risk factor for recurrence. The Kaplan-Meier survival graphs showed that PFS significantly differed in groups categorized based on IFH (p=0.013, log-rank test).

Conclusion

Preoperative IFH was significantly associated with cervical cancer recurrence. [¹?F]FDG based heterogeneity may be a useful and potential predicator of patient recurrence before treatment.

SUBMITTER: Chung HH

PROVIDER: S-EPMC4717220 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Publications

Prognostic value of preoperative intratumoral FDG uptake heterogeneity in early stage uterine cervical cancer.

Chung Hyun Hoon HH Kang Seo Young SY Ha Seunggyun S Kim Jae-Weon JW Park Noh-Hyun NH Song Yong Sang YS Cheon Gi Jeong GJ

Journal of gynecologic oncology 20160301 2

<h4>Objective</h4>We investigated the prognostic value of intratumoral [¹⁸F]fluorodeoxyglucose (FDG) uptake heterogeneity (IFH) derived from positron emission tomography/computed tomography (PET/CT) in patients with cervical cancer.<h4>Methods</h4>Patients with uterine cervical cancer of the International Federation of Obstetrics and Gynecology (FIGO) stage IB to IIA were imaged with [¹⁸F]FDG PET/CT before radical surgery. PET/CT parameters such as maximum and average standardized uptake values ...[more]

PMID: 26768781

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Dataset Information

Prognostic value of preoperative intratumoral FDG uptake heterogeneity in early stage uterine cervical cancer.

Objective

Methods

Results

Conclusion

Publications

Prognostic value of preoperative intratumoral FDG uptake heterogeneity in early stage uterine cervical cancer.

Similar Datasets

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