Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice.
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ABSTRACT:
SUBMITTER: Baar EL
PROVIDER: S-EPMC4717274 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice.
Baar Emma L EL Carbajal Kathryn A KA Ong Irene M IM Lamming Dudley W DW
Aging cell 20151124 1
Inhibition of the mTOR (mechanistic Target Of Rapamycin) signaling pathway robustly extends the lifespan of model organisms including mice. The precise molecular mechanisms and physiological effects that underlie the beneficial effects of rapamycin are an exciting area of research. Surprisingly, while some data suggest that mTOR signaling normally increases with age in mice, the effect of age on mTOR signaling has never been comprehensively assessed. Here, we determine the age-associated changes ...[more]
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