Ontology highlight
ABSTRACT:
SUBMITTER: Chang S
PROVIDER: S-EPMC4717863 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Chang Soyoung S Sung Pil Soo PS Lee Jungsul J Park Junseong J Shin Eui-Cheol EC Choi Chulhee C
Journal of cellular and molecular medicine 20151023 1
Diacylglycerol acyltransferase-1 (DGAT1), a key enzyme in triglyceride (TG) biogenesis, is highly associated with metabolic abnormalities, such as obesity and type 2 diabetes. However, the effects of DGAT1 silencing in the human liver have not been elucidated. To investigate the effects of DGAT1 silencing in human liver cells, we compared the cellular behaviours of DGAT1-deficient Huh-7.5 cell lines with those of control Huh-7.5 cells. DGAT1-deficient cells acquired dedifferentiated and stem cel ...[more]