Ontology highlight
ABSTRACT:
SUBMITTER: Sengelaub CA
PROVIDER: S-EPMC4717998 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Sengelaub Caitlin A CA Navrazhina Kristina K Ross Jason B JB Halberg Nils N Tavazoie Sohail F SF
The EMBO journal 20151130 1
Altered abundance of phosphatidyl inositides (PIs) is a feature of cancer. Various PIs mark the identity of diverse membranes in normal and malignant cells. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) resides predominantly in the plasma membrane, where it regulates cellular processes by recruiting, activating, or inhibiting proteins at the plasma membrane. We find that PTPRN2 and PLCβ1 enzymatically reduce plasma membrane PI(4,5)P2 levels in metastatic breast cancer cells through two indep ...[more]