Unknown

Dataset Information

0

Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation.


ABSTRACT: Multiple sclerosis is the most frequent chronic inflammatory disease of the CNS. The entry and survival of pathogenic T cells in the CNS are crucial for the initiation and persistence of autoimmune neuroinflammation. In this respect, contradictory evidence exists on the role of the most potent type of antigen-presenting cells, dendritic cells. Applying intravital two-photon microscopy, we demonstrate the gatekeeper function of CNS professional antigen-presenting CD11c(+) cells, which preferentially interact with Th17 cells. IL-17 expression correlates with expression of GM-CSF by T cells and with accumulation of CNS CD11c(+) cells. These CD11c(+) cells are organized in perivascular clusters, targeted by T cells, and strongly express the inflammatory chemokines Ccl5, Cxcl9, and Cxcl10. Our findings demonstrate a fundamental role of CNS CD11c(+) cells in the attraction of pathogenic T cells into and their survival within the CNS. Depletion of CD11c(+) cells markedly reduced disease severity due to impaired enrichment of pathogenic T cells within the CNS.

SUBMITTER: Paterka M 

PROVIDER: S-EPMC4718005 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications


Multiple sclerosis is the most frequent chronic inflammatory disease of the CNS. The entry and survival of pathogenic T cells in the CNS are crucial for the initiation and persistence of autoimmune neuroinflammation. In this respect, contradictory evidence exists on the role of the most potent type of antigen-presenting cells, dendritic cells. Applying intravital two-photon microscopy, we demonstrate the gatekeeper function of CNS professional antigen-presenting CD11c(+) cells, which preferentia  ...[more]

Similar Datasets

2004-09-30 | GSE702 | GEO
| S-EPMC6132860 | biostudies-other
| S-EPMC6687568 | biostudies-literature
| S-EPMC5231276 | biostudies-literature
| S-EPMC7806418 | biostudies-literature
| S-EPMC7164247 | biostudies-literature
2023-09-27 | GSE227213 | GEO
2017-12-21 | GSE2215 | GEO
| S-EPMC2791588 | biostudies-literature
| S-EPMC4105169 | biostudies-literature