Ontology highlight
ABSTRACT:
SUBMITTER: Paterka M
PROVIDER: S-EPMC4718005 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Paterka Magdalena M Siffrin Volker V Voss Jan O JO Werr Johannes J Hoppmann Nicola N Gollan René R Belikan Patrick P Bruttger Julia J Birkenstock Jérôme J Jung Steffen S Esplugues Enric E Yogev Nir N Flavell Richard A RA Bopp Tobias T Zipp Frauke F
The EMBO journal 20151126 1
Multiple sclerosis is the most frequent chronic inflammatory disease of the CNS. The entry and survival of pathogenic T cells in the CNS are crucial for the initiation and persistence of autoimmune neuroinflammation. In this respect, contradictory evidence exists on the role of the most potent type of antigen-presenting cells, dendritic cells. Applying intravital two-photon microscopy, we demonstrate the gatekeeper function of CNS professional antigen-presenting CD11c(+) cells, which preferentia ...[more]