Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC4718081 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Liu Haochen H Wei Chunxiang C He Hua H Liu Xiaoquan X
Frontiers in neuroscience 20160119
Aβ, tau, and P-tau have been widely accepted as reliable markers for Alzheimer's disease (AD). The crosstalk between these markers forms a complex network. AD may induce the integral variation and disruption of the network. The aim of this study was to develop a novel mathematic model based on a simplified crosstalk network to evaluate the disease progression of AD. The integral variation of the network is measured by three integral disruption parameters. The robustness of network is evaluated b ...[more]