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Electronegative Low-density Lipoprotein Increases Coronary Artery Disease Risk in Uremia Patients on Maintenance Hemodialysis.


ABSTRACT: Electronegative low-density lipoprotein (LDL) is a recognized factor in the pathogenesis of coronary artery disease (CAD) in the general population, but its role in the development of CAD in uremia patients is unknown. L5 is the most electronegative subfraction of LDL isolated from human plasma. In this study, we examined the distribution of L5 (L5%) and its association with CAD risk in uremia patients.The LDL of 39 uremia patients on maintenance hemodialysis and 21 healthy controls was separated into 5 subfractions, L1-L5, with increasing electronegativity. We compared the distribution and composition of plasma L5 between uremia patients and controls, examined the association between plasma L5% and CAD risk in uremia patients, and studied the effects of L5 from uremia patients on endothelial function.Compared to controls, uremia patients had significantly increased L5% (P?

SUBMITTER: Chang CT 

PROVIDER: S-EPMC4718229 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Electronegative Low-density Lipoprotein Increases Coronary Artery Disease Risk in Uremia Patients on Maintenance Hemodialysis.

Chang Chiz-Tzung CT   Wang Guei-Jane GJ   Kuo Chin-Chi CC   Hsieh Ju-Yi JY   Lee An-Sean AS   Chang Chia-Ming CM   Wang Chun-Cheng CC   Shen Ming-Yi MY   Huang Chiu-Ching CC   Sawamura Tatsuya T   Yang Chao-Yuh CY   Stancel Nicole N   Chen Chu-Huang CH  

Medicine 20160101 2


Electronegative low-density lipoprotein (LDL) is a recognized factor in the pathogenesis of coronary artery disease (CAD) in the general population, but its role in the development of CAD in uremia patients is unknown. L5 is the most electronegative subfraction of LDL isolated from human plasma. In this study, we examined the distribution of L5 (L5%) and its association with CAD risk in uremia patients.The LDL of 39 uremia patients on maintenance hemodialysis and 21 healthy controls was separate  ...[more]

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