Ontology highlight
ABSTRACT:
SUBMITTER: Khoory J
PROVIDER: S-EPMC4718526 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Khoory Joseph J Estanislau Jessica J Elkhal Abdallah A Lazaar Asmae A Melhorn Mark I MI Brodsky Abigail A Illigens Ben B Hamachi Itaru I Kurishita Yasutaka Y Ivanov Alexander R AR Shevkoplyas Sergey S Shapiro Nathan I NI Ghiran Ionita C IC
PloS one 20160119 1
Acute, inflammatory conditions associated with dysregulated complement activation are characterized by significant increases in blood concentration of reactive oxygen species (ROS) and ATP. The mechanisms by which these molecules arise are not fully understood. In this study, using luminometric- and fluorescence-based methods, we show that ligation of glycophorin A (GPA) on human red blood cells (RBCs) results in a 2.1-fold, NADPH-oxidase-dependent increase in intracellular ROS that, in turn, tr ...[more]