Ontology highlight
ABSTRACT:
SUBMITTER: Rees MG
PROVIDER: S-EPMC4718762 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Rees Matthew G MG Seashore-Ludlow Brinton B Cheah Jaime H JH Adams Drew J DJ Price Edmund V EV Gill Shubhroz S Javaid Sarah S Coletti Matthew E ME Jones Victor L VL Bodycombe Nicole E NE Soule Christian K CK Alexander Benjamin B Li Ava A Montgomery Philip P Kotz Joanne D JD Hon C Suk-Yee CS Munoz Benito B Liefeld Ted T Dančík Vlado V Haber Daniel A DA Clish Clary B CB Bittker Joshua A JA Palmer Michelle M Wagner Bridget K BK Clemons Paul A PA Shamji Alykhan F AF Schreiber Stuart L SL
Nature chemical biology 20151214 2
Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established. We hypothesized that differential basal gene expression could be correlated with patterns of small-molecule sensitivity across many cell lines to illuminate the actions of compounds whose MoA are unknown. To test this idea, we correlated the sensitivity patterns of 481 compounds with ∼19,000 basal tr ...[more]