Evolution of an ancient protein function involved in organized multicellularity in animals.
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ABSTRACT:
SUBMITTER: Anderson DP
PROVIDER: S-EPMC4718807 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Evolution of an ancient protein function involved in organized multicellularity in animals.
Anderson Douglas P DP Whitney Dustin S DS Hanson-Smith Victor V Woznica Arielle A Campodonico-Burnett William W Volkman Brian F BF King Nicole N Thornton Joseph W JW Prehoda Kenneth E KE
eLife 20160107
To form and maintain organized tissues, multicellular organisms orient their mitotic spindles relative to neighboring cells. A molecular complex scaffolded by the GK protein-interaction domain (GKPID) mediates spindle orientation in diverse animal taxa by linking microtubule motor proteins to a marker protein on the cell cortex localized by external cues. Here we illuminate how this complex evolved and commandeered control of spindle orientation from a more ancient mechanism. The complex was ass ...[more]
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