Ontology highlight
ABSTRACT:
SUBMITTER: Pembroke WG
PROVIDER: S-EPMC4718813 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Pembroke William G WG Babbs Arran A Davies Kay E KE Ponting Chris P CP Oliver Peter L PL
eLife 20151102
The mammalian suprachiasmatic nucleus (SCN) drives daily rhythmic behavior and physiology, yet a detailed understanding of its coordinated transcriptional programmes is lacking. To reveal the finer details of circadian variation in the mammalian SCN transcriptome we combined laser-capture microdissection (LCM) and RNA-seq over a 24 hr light / dark cycle. We show that 7-times more genes exhibited a classic sinusoidal expression signature than previously observed in the SCN. Another group of 766 g ...[more]