Ontology highlight
ABSTRACT:
SUBMITTER: Fang ZZ
PROVIDER: S-EPMC4718832 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Fang Zhong-Ze ZZ Zhang Dunfang D Cao Yun-Feng YF Xie Cen C Lu Dan D Sun Dong-Xue DX Tanaka Naoki N Jiang Changtao C Chen Qianming Q Chen Yu Y Wang Haina H Gonzalez Frank J FJ
Toxicology and applied pharmacology 20151217
Irinotecan (CPT-11) is a first-line anti-colon cancer drug, however; CPT-11-induced toxicity remains a key factor limiting its clinical application. To search for clues to the mechanism of CPT-11-induced toxicity, metabolomics was applied using ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry. Intraperitoneal injection of 50 mg/kg of CPT-11 induced loss of body weight, and intestine toxicity. Changes in gallbladder morpholog ...[more]