Ontology highlight
ABSTRACT:
SUBMITTER: Budovskaya YV
PROVIDER: S-EPMC4719053 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Budovskaya Yelena V YV Wu Kendall K Southworth Lucinda K LK Jiang Min M Tedesco Patricia P Johnson Thomas E TE Kim Stuart K SK
Cell 20080701 2
To define the C. elegans aging process at the molecular level, we used DNA microarray experiments to identify a set of 1294 age-regulated genes and found that the GATA transcription factors ELT-3, ELT-5, and ELT-6 are responsible for age regulation of a large fraction of these genes. Expression of elt-5 and elt-6 increases during normal aging, and both of these GATA factors repress expression of elt-3, which shows a corresponding decrease in expression in old worms. elt-3 regulates a large numbe ...[more]