Ontology highlight
ABSTRACT:
SUBMITTER: Agarwal V
PROVIDER: S-EPMC4720141 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Agarwal Vinayak V Diethelm Stefan S Ray Lauren L Garg Neha N Awakawa Takayoshi T Dorrestein Pieter C PC Moore Bradley S BS
Organic letters 20150903 18
A chemoenzymatic approach to generate fully functional acyl coenzyme A molecules that are then used as substrates to drive in situ acyl transfer reactions is described. Mass spectrometry based assays to verify the identity of acyl coenzyme A enzymatic products are also illustrated. The approach is responsive to a diverse array of carboxylic acids that can be elaborated to their corresponding coenzyme A thioesters, with potential applications in wide-ranging chemical biology studies that utilize ...[more]