Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish.
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ABSTRACT:
SUBMITTER: Carneiro MC
PROVIDER: S-EPMC4720274 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
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Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish.
Carneiro Madalena C MC Henriques Catarina M CM Nabais Joana J Ferreira Tânia T Carvalho Tânia T Ferreira Miguel Godinho MG
PLoS genetics 20160120 1
Telomeres shorten with each cell division and telomere dysfunction is a recognized hallmark of aging. Tissue proliferation is expected to dictate the rate at which telomeres shorten. We set out to test whether proliferative tissues age faster than non-proliferative due to telomere shortening during zebrafish aging. We performed a prospective study linking telomere length to tissue pathology and disease. Contrary to expectations, we show that telomeres shorten to critical lengths only in specific ...[more]
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