Functional hierarchy underlies preferential connectivity disturbances in schizophrenia.
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ABSTRACT:
SUBMITTER: Yang GJ
PROVIDER: S-EPMC4720350 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Functional hierarchy underlies preferential connectivity disturbances in schizophrenia.
Yang Genevieve J GJ Murray John D JD Wang Xiao-Jing XJ Glahn David C DC Pearlson Godfrey D GD Repovs Grega G Krystal John H JH Anticevic Alan A
Proceedings of the National Academy of Sciences of the United States of America 20151223 2
Schizophrenia may involve an elevated excitation/inhibition (E/I) ratio in cortical microcircuits. It remains unknown how this regulatory disturbance maps onto neuroimaging findings. To address this issue, we implemented E/I perturbations within a neural model of large-scale functional connectivity, which predicted hyperconnectivity following E/I elevation. To test predictions, we examined resting-state functional MRI in 161 schizophrenia patients and 164 healthy subjects. As predicted, patients ...[more]
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