Unknown

Dataset Information

0

Anti-B-Cell Therapies in Autoimmune Neurological Diseases: Rationale and Efficacy Trials.


ABSTRACT: B cells have an ever-increasing role in the etiopathology of a number of autoimmune neurological disorders, acting as antibody-producing cells and, most importantly, as sensors, coordinators, and regulators of the immune response. B cells, among other functions, regulate the T-cell activation process through their participation in antigen presentation and production of cytokines. The availability of monoclonal antibodies or fusion proteins against B-cell surface molecules or B-cell trophic factors bestows a rational approach for treating autoimmune neurological disorders, even when T cells are the main effector cells. This review summarizes basic aspects of B-cell biology, discusses the role(s) of B cells in neurological autoimmunity, and presents anti-B-cell drugs that are either currently on the market or are expected to be available in the near future for treating neurological autoimmune disorders.

SUBMITTER: Alexopoulos H 

PROVIDER: S-EPMC4720683 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Anti-B-Cell Therapies in Autoimmune Neurological Diseases: Rationale and Efficacy Trials.

Alexopoulos Harry H   Biba Angie A   Dalakas Marinos C MC  

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20160101 1


B cells have an ever-increasing role in the etiopathology of a number of autoimmune neurological disorders, acting as antibody-producing cells and, most importantly, as sensors, coordinators, and regulators of the immune response. B cells, among other functions, regulate the T-cell activation process through their participation in antigen presentation and production of cytokines. The availability of monoclonal antibodies or fusion proteins against B-cell surface molecules or B-cell trophic facto  ...[more]

Similar Datasets

| S-EPMC9294112 | biostudies-literature
| S-EPMC7503631 | biostudies-literature
| S-EPMC4637244 | biostudies-literature
| S-EPMC9294117 | biostudies-literature
| S-EPMC7388404 | biostudies-literature
| S-EPMC5184780 | biostudies-literature
| S-EPMC8001105 | biostudies-literature
| S-EPMC7582931 | biostudies-literature
| S-EPMC6121649 | biostudies-other
| S-EPMC5757948 | biostudies-literature