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Anti-B-Cell Therapies in Autoimmune Neurological Diseases: Rationale and Efficacy Trials.

ABSTRACT: B cells have an ever-increasing role in the etiopathology of a number of autoimmune neurological disorders, acting as antibody-producing cells and, most importantly, as sensors, coordinators, and regulators of the immune response. B cells, among other functions, regulate the T-cell activation process through their participation in antigen presentation and production of cytokines. The availability of monoclonal antibodies or fusion proteins against B-cell surface molecules or B-cell trophic factors bestows a rational approach for treating autoimmune neurological disorders, even when T cells are the main effector cells. This review summarizes basic aspects of B-cell biology, discusses the role(s) of B cells in neurological autoimmunity, and presents anti-B-cell drugs that are either currently on the market or are expected to be available in the near future for treating neurological autoimmune disorders.

SUBMITTER: Alexopoulos H

PROVIDER: S-EPMC4720683 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Anti-B-Cell Therapies in Autoimmune Neurological Diseases: Rationale and Efficacy Trials.

Alexopoulos Harry H Biba Angie A Dalakas Marinos C MC

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20160101 1

B cells have an ever-increasing role in the etiopathology of a number of autoimmune neurological disorders, acting as antibody-producing cells and, most importantly, as sensors, coordinators, and regulators of the immune response. B cells, among other functions, regulate the T-cell activation process through their participation in antigen presentation and production of cytokines. The availability of monoclonal antibodies or fusion proteins against B-cell surface molecules or B-cell trophic facto ...[more]

PMID: 26566961

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