Ontology highlight
ABSTRACT:
SUBMITTER: Haslbeck V
PROVIDER: S-EPMC4721540 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Haslbeck Veronika V Drazic Adrian A Eckl Julia M JM Alte Ferdinand F Helmuth Martin M Popowicz Grzegorz G Schmidt Werner W Braun Frank F Weiwad Matthias M Fischer Gunter G Gemmecker Gerd G Sattler Michael M Striggow Frank F Groll Michael M Richter Klaus K
Bioscience reports 20150420 3
Protein phosphatase 5 (PP5) is an evolutionary conserved serine/threonine phosphatase. Its dephosphorylation activity modulates a diverse set of cellular factors including protein kinases and the microtubule-associated tau protein involved in neurodegenerative disorders. It is auto-regulated by its heat-shock protein (Hsp90)-interacting tetratricopeptide repeat (TPR) domain and its C-terminal α-helix. In the present study, we report the identification of five specific PP5 activators [PP5 small-m ...[more]