Ontology highlight
ABSTRACT:
SUBMITTER: Lebedeva NA
PROVIDER: S-EPMC4721542 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Lebedeva Natalia A NA Anarbaev Rashid O RO Sukhanova Maria M Vasil'eva Inna A IA Rechkunova Nadejda I NI Lavrik Olga I OI
Bioscience reports 20150615 4
The influence of poly(ADP-ribose)polymerase 1 (PARP1) on the apurinic/apyrimidinic (AP)-site cleavage activity of tyrosyl-DNA phosphodiesterase 1 (TDP1) and interaction of PARP1 and TDP1 were studied. The efficiency of single or clustered AP-site hydrolysis catalysed by TDP1 was estimated. It was shown that the efficiency of AP-site cleavage increases in the presence of an additional AP-site in the opposite DNA strand depending on its position. PARP1 stimulates TDP1; the stimulation effect was a ...[more]