Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota.
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ABSTRACT:
SUBMITTER: Vetizou M
PROVIDER: S-EPMC4721659 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota.
Vétizou Marie M Pitt Jonathan M JM Daillère Romain R Lepage Patricia P Waldschmitt Nadine N Flament Caroline C Rusakiewicz Sylvie S Routy Bertrand B Roberti Maria P MP Duong Connie P M CP Poirier-Colame Vichnou V Roux Antoine A Becharef Sonia S Formenti Silvia S Golden Encouse E Cording Sascha S Eberl Gerard G Schlitzer Andreas A Ginhoux Florent F Mani Sridhar S Yamazaki Takahiro T Jacquelot Nicolas N Enot David P DP Bérard Marion M Nigou Jérôme J Opolon Paule P Eggermont Alexander A Woerther Paul-Louis PL Chachaty Elisabeth E Chaput Nathalie N Robert Caroline C Mateus Christina C Kroemer Guido G Raoult Didier D Boneca Ivo Gomperts IG Carbonnel Franck F Chamaillard Mathias M Zitvogel Laurence L
Science (New York, N.Y.) 20151105 6264
Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In mice and patients, T cell responses specific for B. thetaiotaomicron or B. fragilis were associated with the efficacy of CTLA-4 blockade. Tumors in antibiotic-treated or germ-free mice did not respond to CTLA blockade. This defect was overcome by gavage with B. fragilis, by immunization with B. fragilis polysaccharides, ...[more]
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