Ontology highlight
ABSTRACT:
SUBMITTER: Vetizou M
PROVIDER: S-EPMC4721659 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20151105 6264
Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In mice and patients, T cell responses specific for B. thetaiotaomicron or B. fragilis were associated with the efficacy of CTLA-4 blockade. Tumors in antibiotic-treated or germ-free mice did not respond to CTLA blockade. This defect was overcome by gavage with B. fragilis, by immunization with B. fragilis polysaccharides, ...[more]