Ontology highlight
ABSTRACT:
SUBMITTER: Werner HM
PROVIDER: S-EPMC4721950 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Werner Halina M HM Cabalteja Chino C CC Horne W Seth WS
Chembiochem : a European journal of chemical biology 20150820 8
The clinical utility of peptides is limited by their rapid degradation by endogenous proteases. Modification of the peptide backbone can generate functional analogues with enhanced proteolytic stability. Existing principles for the design of such oligomers have focused primarily on effective structural mimicry. A more robust strategy would incorporate a rational approach for engineering maximal proteolytic stability with minimal unnatural residue content. We report here the systematic comparison ...[more]