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Tetrahydroberberine, a pharmacologically active naturally occurring alkaloid.

ABSTRACT: Tetrahydroberberine (systematic name: 9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-benzo[g][1,3]benzodioxolo[5,6-a]quinolizine), C20H21NO4, a widely distributed naturally occurring alkaloid, has been crystallized as a racemic mixture about an inversion center. A bent conformation of the molecule is observed, with an angle of 24.72?(5)° between the arene rings at the two ends of the reduced quinolizinium core. The intermolecular hydrogen bonds that play an apparent role in crystal packing are 1,3-benzodioxole -CH2···OCH3 and -OCH3···OCH3 interactions between neighboring molecules.

SUBMITTER: Pingali S 

PROVIDER: S-EPMC4722501 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Tetrahydroberberine, a pharmacologically active naturally occurring alkaloid.

Pingali Subramanya S   Donahue James P JP   Payton-Stewart Florastina F  

Acta crystallographica. Section C, Structural chemistry 20150310 Pt 4

Tetrahydroberberine (systematic name: 9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-benzo[g][1,3]benzodioxolo[5,6-a]quinolizine), C20H21NO4, a widely distributed naturally occurring alkaloid, has been crystallized as a racemic mixture about an inversion center. A bent conformation of the molecule is observed, with an angle of 24.72 (5)° between the arene rings at the two ends of the reduced quinolizinium core. The intermolecular hydrogen bonds that play an apparent role in crystal packing are 1,3-benz  ...[more]

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