Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi J
PROVIDER: S-EPMC4722963 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Takahashi Jack J Orcholski Mark M Yuan Ke K de Jesus Perez Vinicio V
FEBS letters 20160108 1
Pulmonary arterial hypertension (PAH) is characterized by excessive pulmonary arterial smooth muscle cells (PASMCs) growth, partially in response to PDGF-BB but whether this is dependent on β-catenin (βC) activation is unclear. Compared to healthy cells, PAH PASMCs demonstrate higher levels of proliferation both at baseline and with PDGF-BB that correlate with GSK3β dependent βC activation. We show that βC knockdown but not Wnt5a stimulation reduces PDGF-BB dependent growth and normalizes PAH PA ...[more]