SMYD1, an SRF-Interacting Partner, Is Involved in Angiogenesis.
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ABSTRACT:
SUBMITTER: Ye X
PROVIDER: S-EPMC4723226 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
SMYD1, an SRF-Interacting Partner, Is Involved in Angiogenesis.
Ye Xiangli X Qian Yu Y Wang Qian Q Yuan Wuzhou W Mo Xiaoyang X Li Yongqing Y Jiang Zhigang Z Xu Wei W Deng Yun Y Wan Yongqi Y Fan Xiongwei X Wu Xiushan X Wang Yuequn Y
PloS one 20160122 1
Previous studies have demonstrated that Smyd1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization. In this study, we uncovered a novel function of Smyd1 in the regulation of endothelial cells (ECs). Our data showed that Smyd1 is expressed in vascular endothelial cells, and knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation. Furthermore, Co-IP and GST pull-down assays demonstrated that SMYD1 is associated with the S ...[more]
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