Association of transforming growth factor-?1 polymorphisms with the risk of diabetes mellitus.

ABSTRACT: The association between transforming growth factor-?1 (TGF-?1) polymorphisms with the risk of diabetes mellitus (DM) remains elusive. We aimed to evaluate the relationship between TGF-?1 polymorphisms and DM risk. We searched the association studies according to a predefined criteria using electronic databases. The strength of association between TGF-?1 codon 10/25 polymorphisms and the risk of DM was evaluated by odds ratio (OR) with the corresponding 95% confidence interval (CI). Six case-control studies were identified for the analysis of the association between TGF-?1 codon 10/25 polymorphism and the risk of DM. CC genotype at the codon 10 polymorphism was associated with the risk of type 2 DM (T2DM) (P = 0.026, OR = 1.397, 95% CI = 1.041-1.874). No marked association was observed between codon 25 polymorphism and the risk of DM. No evidence of marked publication bias was observed. CC genotype at the TGF-?1 codon 10 site may be an indicator for the risk of T2DM. However, further larger studies should be performed in the future.

SUBMITTER: Mao S 

PROVIDER: S-EPMC4724004 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature