Ontology highlight
ABSTRACT:
SUBMITTER: Echave J
PROVIDER: S-EPMC4724262 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Echave Julian J Spielman Stephanie J SJ Wilke Claus O CO
Nature reviews. Genetics 20160119 2
It has long been recognized that certain sites within a protein, such as sites in the protein core or catalytic residues in enzymes, are evolutionarily more conserved than other sites. However, our understanding of rate variation among sites remains surprisingly limited. Recent progress to address this includes the development of a wide array of reliable methods to estimate site-specific substitution rates from sequence alignments. In addition, several molecular traits have been identified that ...[more]