Does the cognitive architecture of simplex and multiplex ASD families differ?
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ABSTRACT:
SUBMITTER: Oerlemans AM
PROVIDER: S-EPMC4724369 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Does the cognitive architecture of simplex and multiplex ASD families differ?
Oerlemans Anoek M AM Hartman Catharina A CA Franke Barbara B Buitelaar Jan K JK Rommelse Nanda N J NN
Journal of autism and developmental disorders 20160201 2
Children with an autism spectrum disorder (ASD) and their unaffected siblings from 54 simplex (SPX, one individual in the family affected) and 59 multiplex (MPX, two or more individuals affected) families, and 124 controls were assessed on intelligence, social cognition and executive functions. SPX and MPX ASD probands displayed similar cognitive profiles, but within-family contrasts were highest in SPX families, suggesting SPX-MPX stratification may help parse etiological heterogeneity of ASD. ...[more]
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