Kidney Function and Fracture Risk: The Atherosclerosis Risk in Communities (ARIC) Study.

ABSTRACT:

Background

People with end-stage renal disease are at high risk for bone fracture. Less is known about fracture risk in milder chronic kidney disease and whether chronic kidney disease-associated fracture risk varies by sex or assessment with alternative kidney markers.

Study design

Prospective cohort study.

Setting & participants

10,955 participants from the Atherosclerosis Risk in Communities (ARIC) Study followed up from 1996 to 2011.

Predictor

Kidney function as assessed by creatinine-based estimated glomerular filtration rate (eGFRcr), urine albumin-creatinine ratio, and alternative filtration markers.

Outcomes

Fracture-related hospitalizations determined by diagnostic code.

Measurements

Baseline kidney markers; hospitalizations identified by

SUBMITTER: Daya N 

PROVIDER: S-EPMC4724513 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature