Ontology highlight
ABSTRACT:
SUBMITTER: Zhu S
PROVIDER: S-EPMC4724644 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nature chemistry 20160104 2
Amines with remote stereocentres (stereocentres that are three or more bonds away from the C-N bond) are important structural elements in many pharmaceutical agents and natural products. However, previously reported methods to prepare these compounds in an enantioselective manner are indirect and require multistep synthesis. Here, we report a copper-hydride-catalysed, enantioselective synthesis of γ- or δ-chiral amines from readily available allylic alcohols, esters and ethers using a reductive ...[more]