Ontology highlight
ABSTRACT:
SUBMITTER: Rodrigues CP
PROVIDER: S-EPMC4724729 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Rodrigues Cecilia Pessoa CP Ferreira Ana Carolina Franco AC Pinho Mariana Pereira MP de Moraes Cristiano Jacob CJ Bergami-Santos Patrícia Cruz PC Barbuto José Alexandre Marzagão JA
Frontiers in immunology 20160125
Mast cells (MCs) are tissue resident cells, rich in inflammatory mediators, involved in allergic reactions, and with an increasingly recognized role in immunomodulation. Dendritic cells (DCs), on the other hand, are central to the determination of immune response patterns, being highly efficient antigen-presenting cells that respond promptly to changes in their microenvironment. Here, we show that direct cell contact between immature monocyte-derived DCs (iDCs) and MC bends DCs toward tolerance ...[more]