Unknown

Dataset Information

0

Examining non-syndromic autosomal recessive intellectual disability (NS-ARID) genes for an enriched association with intelligence differences.

ABSTRACT: Two themes are emerging regarding the molecular genetic aetiology of intelligence. The first is that intelligence is influenced by many variants and those that are tagged by common single nucleotide polymorphisms account for around 30% of the phenotypic variation. The second, in line with other polygenic traits such as height and schizophrenia, is that these variants are not randomly distributed across the genome but cluster in genes that work together. Less clear is whether the very low range of cognitive ability (intellectual disability) is simply one end of the normal distribution describing individual differences in cognitive ability across a population. Here, we examined 40 genes with a known association with non-syndromic autosomal recessive intellectual disability (NS-ARID) to determine if they are enriched for common variants associated with the normal range of intelligence differences. The current study used the 3511 individuals of the Cognitive Ageing Genetics in England and Scotland (CAGES) consortium. In addition, a text mining analysis was used to identify gene sets biologically related to the NS-ARID set. Gene-based tests indicated that genes implicated in NS-ARID were not significantly enriched for quantitative trait loci (QTL) associated with intelligence. These findings suggest that genes in which mutations can have a large and deleterious effect on intelligence are not associated with variation across the range of intelligence differences.

SUBMITTER: Hill WD 

PROVIDER: S-EPMC4725222 | biostudies-literature | 2016 Jan-Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Examining non-syndromic autosomal recessive intellectual disability (NS-ARID) genes for an enriched association with intelligence differences.

Hill W D WD   Davies G G   Liewald D C DC   Payton A A   McNeil C J CJ   Whalley L J LJ   Horan M M   Ollier W W   Starr J M JM   Pendleton N N   Hansel N K NK   Montgomery G W GW   Medland S E SE   Martin N G NG   Wright M J MJ   Bates T C TC   Deary I J IJ  

Intelligence 20160101

Two themes are emerging regarding the molecular genetic aetiology of intelligence. The first is that intelligence is influenced by many variants and those that are tagged by common single nucleotide polymorphisms account for around 30% of the phenotypic variation. The second, in line with other polygenic traits such as height and schizophrenia, is that these variants are not randomly distributed across the genome but cluster in genes that work together. Less clear is whether the very low range o  ...[more]

Similar Datasets

Unknown Genetics of autosomal recessive intellectual disability.
| S-EPMC6223757 | biostudies-literature
Unknown Mutations in NSUN2 cause autosomal-recessive intellectual disability.
| S-EPMC3376487 | biostudies-literature
Unknown Novel Homozygous TTI2 Variant Causing Autosomal Recessive Syndromic Intellectual Disability and Primary Microcephaly from Pakistan: A Case Report (Exome Report).
| S-EPMC9391182 | biostudies-literature
Unknown PTRHD1 (C2orf79) mutations lead to autosomal-recessive intellectual disability and parkinsonism.
| S-EPMC5318269 | biostudies-literature
Unknown A Novel LINS1 Truncating Mutation in Autosomal Recessive Nonsyndromic Intellectual Disability.
| S-EPMC7247441 | biostudies-literature
Unknown METAP1 mutation is a novel candidate for autosomal recessive intellectual disability.
| S-EPMC7785574 | biostudies-literature
Unknown Novel variants underlying autosomal recessive intellectual disability in Pakistani consanguineous families.
| S-EPMC7092478 | biostudies-literature
Unknown Bi-allelic Variants in METTL5 Cause Autosomal-Recessive Intellectual Disability and Microcephaly.
| S-EPMC6817559 | biostudies-literature
Unknown B3GALNT2 mutations associated with non-syndromic autosomal recessive intellectual disability reveal a lack of genotype-phenotype associations in the muscular dystrophy-dystroglycanopathies.
| S-EPMC5740572 | biostudies-literature
Unknown Mutations in the alpha 1,2-mannosidase gene, MAN1B1, cause autosomal-recessive intellectual disability.
| S-EPMC3135808 | biostudies-literature