Ontology highlight
ABSTRACT:
SUBMITTER: Yin Z
PROVIDER: S-EPMC4725323 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Yin Zhaojun Z Chowdhury Sudipa S McKay Craig C Baniel Claire C Wright W Shea WS Bentley Philip P Kaczanowska Katarzyna K Gildersleeve Jeffrey C JC Finn M G MG BenMohamed Lbachir L Huang Xuefei X
ACS chemical biology 20150811 10
Development of an effective vaccine targeting tumor associated carbohydrate antigens (TACAs) is an appealing approach toward tumor immunotherapy. While much emphasis has been typically placed on generating high antibody titers against the immunizing antigen, the impact of immunogen design on the diversity of TACA-specific antibodies elicited has been overlooked. Herein, we report that the immunogen structure can significantly impact the breadth and the magnitude of humoral responses. Vaccine con ...[more]