Ontology highlight
ABSTRACT:
SUBMITTER: Ferreira VP
PROVIDER: S-EPMC4725370 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Ferreira Viviana P VP Fazito Vale Vladimir V Pangburn Michael K MK Abdeladhim Maha M Mendes-Sousa Antonio Ferreira AF Coutinho-Abreu Iliano V IV Rasouli Manoochehr M Brandt Elizabeth A EA Meneses Claudio C Lima Kolyvan Ferreira KF Nascimento Araújo Ricardo R Pereira Marcos Horácio MH Kotsyfakis Michalis M Oliveira Fabiano F Kamhawi Shaden S Ribeiro Jose M C JM Gontijo Nelder F NF Collin Nicolas N Valenzuela Jesus G JG
Scientific reports 20160113
Blood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Sand fly saliva was shown to inhibit the classical pathway of complement; however, the molecular identity of the inhibitor remains unknown. Here, we identified SALO as the classical pathway complement inhibitor. SALO, an 11 kDa protein, has no homology to proteins of any other organism apart from New World sand flies. rSALO anti-complement activity has the same ...[more]