Ontology highlight
ABSTRACT:
SUBMITTER: Titz B
PROVIDER: S-EPMC4725611 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Titz Bjoern B Boué Stéphanie S Phillips Blaine B Talikka Marja M Vihervaara Terhi T Schneider Thomas T Nury Catherine C Elamin Ashraf A Guedj Emmanuel E Peck Michael J MJ Schlage Walter K WK Cabanski Maciej M Leroy Patrice P Vuillaume Gregory G Martin Florian F Ivanov Nikolai V NV Veljkovic Emilija E Ekroos Kim K Laaksonen Reijo R Vanscheeuwijck Patrick P Peitsch Manuel C MC Hoeng Julia J
Toxicological sciences : an official journal of the Society of Toxicology 20151117 2
The impact of cigarette smoke (CS), a major cause of lung diseases, on the composition and metabolism of lung lipids is incompletely understood. Here, we integrated quantitative lipidomics and proteomics to investigate exposure effects on lung lipid metabolism in a C57BL/6 and an Apolipoprotein E-deficient (Apoe(-/-)) mouse study. In these studies, mice were exposed to high concentrations of 3R4F reference CS, aerosol from potential modified risk tobacco products (MRTPs) or filtered air (Sham) f ...[more]